祝贺实验室张世龙（硕士生）与朱笑笑（本科生）的论文被Org Chem Front接收发表！
发布时间：2026-09-30 14:32:55
Visible-light-driven radical difluoroalkylation/cyclization of N-allyl and N-homoallyl aldehyde hydrazones with [Ph3PCF2H]+Br-
Jinkui Chai,a Lili Wang,a Shilong Zhang,a Xiaoxiao Zhu,a Jinwei Yuan,a,* Yongmei Xiao,a Shouren Zhang,b,* Lingbo Quc,d,*
Organic Chemistry Frontiers, 2026, DOI: 10.1039/d6qo01138a.
A visible-light-driven radical difluoroalkylation/cyclization of N-allyl and N-homoallyl aldehyde hydrazones is reported using readily accessible bromodifluoromethylphosphonium bromide ([Ph3PCF2H]+Br-) as a bench-stable difluoromethyl radical source. This transformation enables efficient access to difluoroalkyl-substituted dihydropyrazoles and tetrahydropyridazines under mild, additive- and base-free conditions. Selected dihydropyrazole products also undergo a subsequent photocatalytic dehydrogenation to give the corresponding difluoroalkylated pyrazoles. Preliminary mechanistic investigations suggest that the reaction proceeds via a difluoromethyl radical-mediated cascade cyclization pathway.
Jinkui Chai,a Lili Wang,a Shilong Zhang,a Xiaoxiao Zhu,a Jinwei Yuan,a,* Yongmei Xiao,a Shouren Zhang,b,* Lingbo Quc,d,*
Organic Chemistry Frontiers, 2026, DOI: 10.1039/d6qo01138a.
A visible-light-driven radical difluoroalkylation/cyclization of N-allyl and N-homoallyl aldehyde hydrazones is reported using readily accessible bromodifluoromethylphosphonium bromide ([Ph3PCF2H]+Br-) as a bench-stable difluoromethyl radical source. This transformation enables efficient access to difluoroalkyl-substituted dihydropyrazoles and tetrahydropyridazines under mild, additive- and base-free conditions. Selected dihydropyrazole products also undergo a subsequent photocatalytic dehydrogenation to give the corresponding difluoroalkylated pyrazoles. Preliminary mechanistic investigations suggest that the reaction proceeds via a difluoromethyl radical-mediated cascade cyclization pathway.