恭喜实验室刘贝（硕研）的文章被 Chem Commun（中科院2区）接收发表！
发布时间：2026-06-25 07:51:22
Photocatalyst-free EDA complex-enabled radical difluoroalkylation/cyclization for access to difluoroalkylated polycyclic coumarin derivatives
Bei Liu,a Yongmei Xiao,a,* Lili Wang,a Shilong Zhang,a Meng Yan,a,* Yuntao Xia,a Jinwei Yuan,a,*
Bei Liu,a Yongmei Xiao,a,* Lili Wang,a Shilong Zhang,a Meng Yan,a,* Yuntao Xia,a Jinwei Yuan,a,*
Chem. Commun., 2026,62, 11891-11895.
A photocatalyst-free and electron donor–acceptor (EDA)-complex-enabled radical difluoroalkylation/cyclization of unactivated alkenes with bromodifluoroacetamides has been developed for the efficient synthesis of difluoroalkyl-containing polycyclic coumarin derivatives, affording a total of 32 target compounds. In this transformation, persulfates act as electron donors and bromodifluoroacetamides serve as electron acceptors to generate an EDA complex, enabling visible-light-induced radical processes without the need for external photocatalysts. This method features mild reaction conditions, operational simplicity, metal-free nature, and broad functional group tolerance.