恭喜实验室刘启阳（研究生）的文章被 Green Synth Catal (中科院1区，TOP)接收发表！

发布时间：2026-03-02 19:09:52

Photocatalytic radical amination/cyclization of N-allyl and N-homoallyl aldehyde hydrazones: access to sulfonaminated pyrazoles and tetrahydropyridazines
Qi-Yang Liu^a,†, Zi-Heng Yu^b,†, Li-Li Wang^a, Jin-Wei Yuan^a,*, Yun-Tao Xia^a,*, Liang-Ru Yang^a, Yong-Mei Xiao^a, Ling-Bo Qu^c,d,*
Green Synth. Catal. 2026, Accepted.

A visible-light-driven photocatalytic strategy for the sulfonamidation/cyclization of N-allyl and N-homoallyl aldehyde hydrazones is described, employing N-aminopyridinium salts as sulfonylamino radical precursors. This transformation enables efficient access to sulfonylamino-substituted pyrazoles and tetrahydropyridazines under mild conditions. This protocol exhibits broad substrate scope, good to excellent yields, and excellent scalability. Preliminary mechanistic investigations suggest that the reaction proceeds via a sulfonamino radical-mediated cascade cyclization pathway. Notably, the N-aminopyridinium salts serve a dual role both sulfonamination reagents and hydrogen-atom transfer mediators, enabling the one-step synthesis of sulfonylamidated pyrazoles.