恭喜实验室硕士吕韦贤的文章被Chem Commun接收发表！
发布时间：2025-09-19 14:35:25
Photo-triggered radical cyclization of arylethynyl quinazolin-4(3H)-ones to access difluoroalkylated quinolino[2,1-b]quinazolines
Haibo Yao,a,* Qiyang Liu,b Jinwei Yuan,b,* Weixian Lv,b Liangru Yang,b Yongmei Xiao,b Yuntao Xia,b Dongliang Xing,c,*
Abstract: A photoinduced cascade difluoroalkylation/cyclization reaction of unactivated arylethynyl quinazolin-4(3H)-ones with ethyl iododifluoroacetates or iododifluoramides has been developed. This transformation enables the construction of difluoroalkylated quinolino[2,1-b]quinazoline derivatives via consecutive intramolecular dual cyclization processes. It features mild reaction conditions, a broad substrate scope and moderate to good yields.
Haibo Yao,a,* Qiyang Liu,b Jinwei Yuan,b,* Weixian Lv,b Liangru Yang,b Yongmei Xiao,b Yuntao Xia,b Dongliang Xing,c,*
Abstract: A photoinduced cascade difluoroalkylation/cyclization reaction of unactivated arylethynyl quinazolin-4(3H)-ones with ethyl iododifluoroacetates or iododifluoramides has been developed. This transformation enables the construction of difluoroalkylated quinolino[2,1-b]quinazoline derivatives via consecutive intramolecular dual cyclization processes. It features mild reaction conditions, a broad substrate scope and moderate to good yields.