恭喜实验室研究生张世龙的文章被 Asian J. Org. Chem. 接收！
发布时间：2025-07-11 17:26:02
Photoredox-catalyzed difluoromethylation/cyclization of N-cyanamide alkenes to acess difluoromethylated polycyclic quinazolinnes
Jinwei Yuan,a,* Shilong Zhang,a Meng Yan,a Liangru Yang,a Yongmei Xiao,a Shouren Zhang,b,* Lingbo Quc,d
An efficient photoinduced radical cascade difluoromethylation/cyclization reaction of N-cyanamide alkenes has been developed. A diverse range of difluoromethylated quinazolinones have been synthesized with good yields and broad functional group tolerance. This photocatalytic protocol offers a facile and practical approach to accessing valuable polycyclic quinazolinone derivatives. Preliminary mechanistic studies suggest that the transformation proceeds via a radical pathway involving single electron transfer (SET).
Jinwei Yuan,a,* Shilong Zhang,a Meng Yan,a Liangru Yang,a Yongmei Xiao,a Shouren Zhang,b,* Lingbo Quc,d
An efficient photoinduced radical cascade difluoromethylation/cyclization reaction of N-cyanamide alkenes has been developed. A diverse range of difluoromethylated quinazolinones have been synthesized with good yields and broad functional group tolerance. This photocatalytic protocol offers a facile and practical approach to accessing valuable polycyclic quinazolinone derivatives. Preliminary mechanistic studies suggest that the transformation proceeds via a radical pathway involving single electron transfer (SET).