# 112 Recent dvances in the photocatalytic synthesis of isoquinoline-1,3-dione derivatives
Recent dvances in the photocatalytic synthesis of isoquinoline-1,3-dione derivatives
Wei Lian, Bei Liu, Qi-Yang Liu and Jin-Wei Yuan*
Org. Biomol. Chem., 2025, Accepted Manuscript
https://doi.org/10.1039/D5OB01730K
Isoquinoline-1,3(2
H,4
H)-diones constitute an important class of nitrogen-containing heterocycles that are broadly distributed in natural products and bioactive pharmaceutical compounds, exhibiting diverse biological activities. In recent years, visible-light photocatalysis has emerged as a powerful and sustainable approach in organic synthesis, offering green, mild, and highly efficient reaction conditions. This review summarises the latest progress in the visible-light-driven synthesis of functionalized isoquinoline-1,3-dione derivatives, with particular emphasis on the photocatalytic cyclization of
N-acryloylbenzamides with carbon-, sulfur-, phosphorus-, selenium-, and other radical precursors. The mechanistic features and synthetic applications of key transformations, including alkylation, fluoroalkylation, acylation, arylation, sulfonylation, are discussed in detail. Finally, the review provides an outlook on current challenges and perspective developments in this rapidly evolving field.