# 120 Photo-triggered tandem cyclization of arylethynyl quinazolin-4(3H)-one for difluoroalkylated quinolino[2,1-b]quina
发布时间：2025-12-18 15:17:45
Photo-triggered tandem cyclization of arylethynyl quinazolin-4(3H)-one for difluoroalkylated quinolino[2,1-b]quinazolines
Haibo Yao,a Qiyang Liu,b Jinwei Yuan, *b Weixian Lv,b Liangru Yang, b Yongmei Xiao,b Yuntao Xia b and Dongliang Xing*c
Chem. Commun., 2025, 61, 16596–16599. http://doi.org/10.1039/d5cc04514b
A photoinduced cascade difluoroalkylation/cyclization reaction of arylethynyl quinazolin-4(3H)-ones with ethyl iododifluoroacetates or iododifluoramides has been developed. This transformation enables the construction of difluoroalkylated quinolino[2,1-b]quinazoline derivatives via consecutive intramolecular dual cyclization processes. It features mild reaction conditions, a broad substrate scope and moderate to good yields.
Haibo Yao,a Qiyang Liu,b Jinwei Yuan, *b Weixian Lv,b Liangru Yang, b Yongmei Xiao,b Yuntao Xia b and Dongliang Xing*c
Chem. Commun., 2025, 61, 16596–16599. http://doi.org/10.1039/d5cc04514b
A photoinduced cascade difluoroalkylation/cyclization reaction of arylethynyl quinazolin-4(3H)-ones with ethyl iododifluoroacetates or iododifluoramides has been developed. This transformation enables the construction of difluoroalkylated quinolino[2,1-b]quinazoline derivatives via consecutive intramolecular dual cyclization processes. It features mild reaction conditions, a broad substrate scope and moderate to good yields.