# 117 Visible-Light-Driven Tandem Cyclization of o‑Hydroxyaryl Enaminones: Access to 3‑(α-Arylsulfonamido)trifluor
发布时间：2025-03-12 18:41:06
Visible-Light-Driven Tandem Cyclization of o‑Hydroxyaryl Enaminones: Access to 3‑(α-Arylsulfonamido)trifluoroethyl Chromones
Jinwei Yuan,* Qiyang Liu, Xuanlin Liu, Da Wang, Meng Yan,* Xianghui Meng, Ji Ma,* and Lingbo Qu
J. Org. Chem. 2025, 90, 6031−6043. https://doi.org/10.1021/acs.joc.5c00424
A visible-light-driven intermolecular tandem a-amidotrifluoroethylation/ cyclization of enaminones using a previously unreported N-trifluoroethylaminopyridinium salt was achieved in the absence of transition metal catalysts, or bases. Notable features of this synthetic method include mild conditions, high selectivity, excellent functional group compatibility, and satisfactory yields. Preliminary mechanistic studies indicate that the reaction proceeds via a radical pathway, involving an in situ generated N-trifluoroethyl radical followed by a 1,2-H shift.
Jinwei Yuan,* Qiyang Liu, Xuanlin Liu, Da Wang, Meng Yan,* Xianghui Meng, Ji Ma,* and Lingbo Qu
J. Org. Chem. 2025, 90, 6031−6043. https://doi.org/10.1021/acs.joc.5c00424
A visible-light-driven intermolecular tandem a-amidotrifluoroethylation/ cyclization of enaminones using a previously unreported N-trifluoroethylaminopyridinium salt was achieved in the absence of transition metal catalysts, or bases. Notable features of this synthetic method include mild conditions, high selectivity, excellent functional group compatibility, and satisfactory yields. Preliminary mechanistic studies indicate that the reaction proceeds via a radical pathway, involving an in situ generated N-trifluoroethyl radical followed by a 1,2-H shift.