# 113 Photocatalytic radical cascade arylthiolation/cyclization of 3-(2-(ethynyl)phenyl)quinazolinones with disulfides l
发布时间：2024-10-18 15:16:40
Photocatalytic radical cascade arylthiolation/cyclization of 3-(2-(ethynyl)phenyl)quinazolinones with disulfides leading to arylthiolated quinolino[2,1-b]quinazolinones
Fanlin Zeng,a Jinwei Yuan,b,* Junru Jiang,b Meiyue Zhang,b Sanyu Zhang,b Jinling Li,a,* Liangru Yang,b Yongmei Xiao,b Lingbo Quc,d
A convenient approach to the synthesis of arylthiolated quinolino[2,1-b]quinazolinones has been developed using unactivated alkynes containing quinazolinones and diaryldisulfides under visible light irradiation. The procedure entails a sequential radical arylthiolation and cyclization reaction. Additionally, this reaction exhibits notable characteristics, including a broad substrate scope, excellent functional group tolerance, mild conditions and a simple operational procedure.
Fanlin Zeng,a Jinwei Yuan,b,* Junru Jiang,b Meiyue Zhang,b Sanyu Zhang,b Jinling Li,a,* Liangru Yang,b Yongmei Xiao,b Lingbo Quc,d
First published: 16 September 2024
Advanced Synthesis & Catalysis, 2024, Doi: 10.1002/adsc.202400960
https://doi.org/10.1002/adsc.202400960
Advanced Synthesis & Catalysis, 2024, Doi: 10.1002/adsc.202400960
https://doi.org/10.1002/adsc.202400960
A convenient approach to the synthesis of arylthiolated quinolino[2,1-b]quinazolinones has been developed using unactivated alkynes containing quinazolinones and diaryldisulfides under visible light irradiation. The procedure entails a sequential radical arylthiolation and cyclization reaction. Additionally, this reaction exhibits notable characteristics, including a broad substrate scope, excellent functional group tolerance, mild conditions and a simple operational procedure.