# 112 Acid-catalyzed radical tandem alkylation/cyclization of unactivated alkenes with ketones: Access to ketoalkyl-subs
发布时间：2024-10-18 15:14:00
Acid-catalyzed radical tandem alkylation/cyclization of unactivated alkenes with ketones: Access to ketoalkyl-substituted quinazolinone derivatives
Jianli Wu,a Meng Yan,b Lulu Fan,b Wei Lian,b Chenxu Mou,b Jinwei Yuan,b,* Yongmei Xiao,b Dongliang Xingc,*
A method for synthesizing polycyclic quinazolinone derivatives with ketoalkyl substitutions has been developed through strong acid-catalyzed radical tandem alkylation/cyclization of unactivated alkenes with readily available ketones under microwave irradiation. The transformation offers several advantages, including wide functional group compatibility, operational simplicity, and moderate to good yields. This methodology offers an appealing approach to obtaining keto-containing polycyclic quinazolinones with pharmaceutical value.
Jianli Wu,a Meng Yan,b Lulu Fan,b Wei Lian,b Chenxu Mou,b Jinwei Yuan,b,* Yongmei Xiao,b Dongliang Xingc,*
A method for synthesizing polycyclic quinazolinone derivatives with ketoalkyl substitutions has been developed through strong acid-catalyzed radical tandem alkylation/cyclization of unactivated alkenes with readily available ketones under microwave irradiation. The transformation offers several advantages, including wide functional group compatibility, operational simplicity, and moderate to good yields. This methodology offers an appealing approach to obtaining keto-containing polycyclic quinazolinones with pharmaceutical value.