# 111 Visible-light-induced photocatalyst-free cascade cyclization of 3-(2-(ethynyl)phenyl)quinazolinones to sulfonated
发布时间：2024-10-18 14:54:30
Visible-light-induced photocatalyst-free cascade cyclization of 3-(2-(ethynyl)phenyl)quinazolinones to sulfonated quinolino[2,1-b]quinazolinones
Fan-Lin Zeng,a Yu-Xin Luo,a Jia-Nan Chen,a Jinling Li,a* and Jinwei Yuanb*
The article was first published on 17 Jun 2024
Chem. Commun., 2024,60, 7228-7231
https://doi.org/10.1039/D4CC01970A
A visible-light-promoted K2S2O8-catalysed cascade sulfonation/cyclization reaction was established using 3-(2-(ethynyl)phenyl)quinazolinones as efficient substrates under mild conditions. A series of sulfonated quinolino[2,1-b]quinazolinones (30 examples, up to 90% yield, including pharmaceuticals) was first successfully synthesized using MeCN as a solvent and avoided transition metals and photocatalysts. Notably, this strategy has the advantages of room temperature, easy scale-up, simple operation, and good functional group tolerance.
Fan-Lin Zeng,a Yu-Xin Luo,a Jia-Nan Chen,a Jinling Li,a* and Jinwei Yuanb*
The article was first published on 17 Jun 2024
Chem. Commun., 2024,60, 7228-7231
https://doi.org/10.1039/D4CC01970A
A visible-light-promoted K2S2O8-catalysed cascade sulfonation/cyclization reaction was established using 3-(2-(ethynyl)phenyl)quinazolinones as efficient substrates under mild conditions. A series of sulfonated quinolino[2,1-b]quinazolinones (30 examples, up to 90% yield, including pharmaceuticals) was first successfully synthesized using MeCN as a solvent and avoided transition metals and photocatalysts. Notably, this strategy has the advantages of room temperature, easy scale-up, simple operation, and good functional group tolerance.