# 110 Visible-Light-Promoted Deoxygenative Alkylation of Quinoxalin-2(1H)‑ones with Activated Alcohols
发布时间：2024-03-07 08:43:07
Visible-Light-Promoted Deoxygenative Alkylation of Quinoxalin-2(1H)‑ones with Activated Alcohols
Lili Wang,a Pengyuan Yang,a Jinwei Yuan,a,* Wei Lian,a Xinrong Jin,a Sanyu Zhang,a Liangru Yang,a,* Dongliang Xingb,*The Journal of Organic Chemistry 2024, 89, 6334-6344. (Article)
Publication Date (Web):April 15, 2024DOI: 10.1021/acs.joc.4c00309
A one-pot strategy for deoxygenative alkylation reaction of alcohols with quinoxalin-2(1H)-ones was developed by using xanthate salts as alcohol-activating groups for radical generation in the presence of tricyclohexylphosphine under visible-light-promoted conditions. Remarkable features of this reaction include broad substrate scope, excellent functional group tolerance, mild conditions and simple operation. Moreover, the synthetic utility of this reaction was validated by the success of two-step one-pot reactions, scale-up synthesis and chemoselective radical monodeoxygenation of diols.