# 106 Photoredox-Catalyzed Three-Component Difluoroalkylation of Quinoxalin-2(1H)-ones with Unactivated Vinylarenes and
发布时间：2024-01-11 12:32:07
Photoredox-Catalyzed Three-Component Difluoroalkylation of Quinoxalin-2(1H)-ones with Unactivated Vinylarenes and [Ph3PCF2H]+Br-
Yuandong Xu,a Hongzhao Qu,a Jinwei Yuan,a,*Na Guo,b Liangru Yang,a,* Yanli Yin,b Lingbo Qu,c Jian Maod
Asian Journal of Organic Chemistry 2023, 12, 11, e202300405.
https://doi.org/10.1002/ajoc.202300405
An efficient synthesis of a variety of 3-difluoroalkyl quinoxalin-2(1H)-ones via a photoredox-catalyzed three-component reaction between quinoxalin-2(1H)-ones, vinylarenes, with inexpensive and easily accessible difluoromethyltriphenylphosphonium bromide salt as the difluoromethylated reagent is described. This protocol shows excellent reactivity, providing a wide range of difluoroalkyl-substituted quinoxalin-2(1H)-ones in moderate to excellent yields under mild conditions. A difluoroalkyl radical intermediate was involved in this three-component transformation.
Yuandong Xu,a Hongzhao Qu,a Jinwei Yuan,a,*Na Guo,b Liangru Yang,a,* Yanli Yin,b Lingbo Qu,c Jian Maod
Asian Journal of Organic Chemistry 2023, 12, 11, e202300405.
https://doi.org/10.1002/ajoc.202300405
An efficient synthesis of a variety of 3-difluoroalkyl quinoxalin-2(1H)-ones via a photoredox-catalyzed three-component reaction between quinoxalin-2(1H)-ones, vinylarenes, with inexpensive and easily accessible difluoromethyltriphenylphosphonium bromide salt as the difluoromethylated reagent is described. This protocol shows excellent reactivity, providing a wide range of difluoroalkyl-substituted quinoxalin-2(1H)-ones in moderate to excellent yields under mild conditions. A difluoroalkyl radical intermediate was involved in this three-component transformation.