# 103 Visible-light induced cascade cyclizaiton of 1-acryloyl-2-cyanoindole：Access of difluoroalkylated pyrrolo[1,2-a]
发布时间：2023-01-16 18:26:31
Visible-light induced cascade cyclizaiton of 1-acryloyl-2-cyanoindole：Access of difluoroalkylated pyrrolo[1,2-a]indolediones
Jinwei Yuan,a,* Lu Shen,a Na Guo,b Yanli Yin,b Liangru Yang,a,* Yongmei Xiao,a Shouren Zhang,c
J. Org. Chem. 2023, 88, 23, 16598-16608
https://pubs.acs.org/doi/10.1021/acs.joc.3c02183
An efficient visible-light-induced PhI(OAc)2-promoted cascade difluoroalkylation/cyclization reaction to access various difluoroalkylated pyrrolo[1,2-a]indolediones was developed using a,a-difluoroarylacetic acids as the difluoroalkylation reagent under mild conditions. Notably, the present transformation was carried out with DMSO-H2O as a green medium at room temperature, and photocatalysts could be effectively avoided. The reactions are simple to operate, easy to scale up, good to excellent yields, and have good functional group tolerance.
Jinwei Yuan,a,* Lu Shen,a Na Guo,b Yanli Yin,b Liangru Yang,a,* Yongmei Xiao,a Shouren Zhang,c
J. Org. Chem. 2023, 88, 23, 16598-16608
https://pubs.acs.org/doi/10.1021/acs.joc.3c02183
An efficient visible-light-induced PhI(OAc)2-promoted cascade difluoroalkylation/cyclization reaction to access various difluoroalkylated pyrrolo[1,2-a]indolediones was developed using a,a-difluoroarylacetic acids as the difluoroalkylation reagent under mild conditions. Notably, the present transformation was carried out with DMSO-H2O as a green medium at room temperature, and photocatalysts could be effectively avoided. The reactions are simple to operate, easy to scale up, good to excellent yields, and have good functional group tolerance.